ICU-acquired weakness

Surviving critical illness: what is next? An expert consensus statement on physical rehabilitation after hospital discharge

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5086052/

Crit Care. 2016; 20: 354. 

Published online 2016 Oct 29. doi:  10.1186/s13054-016-1508-x

M. E. Major,1,2 R. Kwakman,1 M. E. Kho,3 B. Connolly,4 D. McWilliams,5 L. Denehy,6 S. Hanekom,7 S. Patman,8 R. Gosselink,9 C. Jones,10 F. Nollet,11 D. M. Needham,12,13,14 R. H. H. Engelbert,1,11 and  M. van der Schaafcorresponding author1,11

13054_2016_1508_Fig2_HTML.jpg


Impact van een intensive-care-opname

2016_Sommers-Schaaf_Fysiopraxis__2016_pg22-25.pdf


Van de beademing af dank zij NExCOB 2016

Journalist en voormalig ic patient Rob Bruntink sprak met een intensivist van Radboudumc, Hans van der Hoeven, die samen met collega-intensivst Leo Heunks het Nijmeegs Expertisecentrum voor de Ontwenning van Beademing (NExCOB) was gestart. Hoewel het nog maar kort bestaat, zijn de resultaten uiterst bemoedigend. Hij schreef er op de website www.opeenicliggen.nl een artikel over: http://www.opeenicliggen.nl/apparatuur-2/nijmeegs-expertisecentrum-voor-de-ontwenning-van-beademing-nexcob/ 

Impact of ICU-acquired weakness on post-ICU physical functioning: a follow-up study 

Wieske et al. Critical Care (2015) 19:196 DOI 10.1186/s13054-015-0937-2 

Luuk Wieske1,2*,Daniela S Dettling-Ihnenfeldt3, Camiel Verhamme2, Frans Nollet3, Ivo N van Schaik2, Marcus J Schultz1, Janneke Horn1† and Marike van der Schaaf3† Wieske_ImpactICUAW_CritCare_2015.pdf

---------------------------------------------------------------------------------------------------------------------------

Physiotherapy in the intensive care unit: an evidence-based, expert driven, practical statement and rehabilitation recommendations 
Juultje Sommers1, Raoul HH Engelbert1,2,
Daniela Dettling-Ihnenfeldt1, Rik Gosselink3, Peter E Spronk4, Frans Nollet1 and Marike van der Schaaf1 
 

------------------------------------------------------------------------------------------------------------------------

Interview with LIVES 2014 Keynote Speaker

In this icTV interview, LIVES 2014 Keynote Speaker Margaret Herridge discusses how to adapt daily ICU practice to impact long-term outcomes in patients. Modifying medication, early mobilisation and other such approaches are noted.

http://www.esicm.org/news-article/icTV-interview-long-term-outcomes-HerridgeAttendMargaret Herridge's Keynote "ICU ACQUIRED WEAKNESS: CLINICAL PHENOTYPES AND DETERMINANTS" at LIVES 2014.

---------------------------------------------------------------------------------------------------------------------------

Een expert van de Universiteit van Chicago Medical Center verteld over het vroeg mobiliseren van patienten Een Multi-disciplinaire benadering bij het mobiliseren van Intensive care patienten Klik op de afbeelding om het filmpje te zien 

weakness.jpg


Clinical review: intensive care unit acquired weakness

Greet Hermans and Greet Van den Berghe 

05-08-2015  http://www.ccforum.com/content/19/1/274


Critical Illness Polyneuropathy and Polymyopathy
door Darren Hudson. september 2016 Klil op de afbeelding om het filmpje te bekijken 
 
weakness_2.jpg
 


Early Mobilization/Physiotherapy & Occupational Therapy

Research studies

Affleck AT, Lieberman S, Polon J, Rohrkemper K. Providing occupational therapy in an intensive care unit. Am J Occup Ther. 1986 May;40(5):323-32. PubMed PMID: 3717268

Blair SN, Kohl HW 3rd, Paffenbarger RS Jr, Clark DG, Cooper KH, Gibbons LW. Physical fitness and all-cause mortality A prospective study of healthy men and women. JAMA. 1989 Nov 3;262(17):2395-401

Chang AT, Boots RJ, Hodges PW, Thomas PJ, Paratz JD (2004): Standing with the assistance of a tilt table improves minute ventilation in chronic critically ill patients. Arch Phys Med Rehabil. 2004 Dec;85(12):1972-6.

Zafiropoulos B, Alison JA, McCarren B: Physiological responses to the early mobilisation of the intubated, ventilated abdominal surgery patient. Aust J Physiother 2004;50(2):95-100 free full text

Stiller K, Phillips AC, Lambert P. The safety of mobilisation and its effect on haemodynamic and respiratory status of intensive care patients. Physiotherapy Theory and Practice, 2004 20: 175-185

Perme CS, Southard RE, Joyce DL, Noon GP, Loebe M: Early mobilization of LVAD recipients who require prolonged mechanical ventilation. Tex Heart Inst J. 2006;33(2):130-3. free full text

Dieperink W, Goorhuis JF, de Weerd W, Hazenberg A, Zijlstra JG, Nijsten MW. (2006): Walking with continuous positive airway pressure. Eur Respir J. Apr; 27(4):853-5 free full text

Bailey P, Thomsen GE, Spuhler VJ, Blair R, Jewkes J, Bezdjian L, Veale K, Rodriquez L, Hopkins RO: Early activity is feasible and safe in respiratory failure patients. Crit Care Med. 2007 Jan;35(1): 139-45

Morris PE, Goad A, Thompson C, Taylor K, Harry B, Passmore L, Ross A, Anderson L, Baker S, Sanchez M, Penley L, Howard A, Dixon L, Leach S, Small R, Hite RD, Haponik E.: Early intensive care unit mobility therapy in the treatment of acute respiratory failure. Crit Care Med. 2008 Aug;36(8):2238-43.

McWilliams DJ, Pantelides KP.: Does physiotherapy led early mobilisation affect length of stay on ICU? ACPRC Journal 2008 40, 5-11

Fan E, Needham DM. The science of quality improvement. JAMA. 2008 Jul 23;300(4):390-1

Pronovost PJ, Berenholtz SM, Goeschel C, Thom I, Watson SR, Holzmueller CG, Lyon JS, Lubomski LH, Thompson DA, Needham D, Hyzy R, Welsh R, Roth G, Bander J, Morlock L, Sexton JB. Improving patient safety in intensive care units in Michigan. J Crit Care. 2008 Jun;23(2):207-21

Pronovost PJ, Berenholtz SM, Needham DM. Translating evidence into practice: a model for large scale knowledge translation. BMJ. 2008 Oct 6;337:a1714

Perme C, Chandrashekar R. Managing the patient on Mechanical Ventilation in ICU:  Early Mobility and Walking Program. Acute Care Perspectives. Spring 2008, Vol 17, Number 1, 10-15. free text

Thomsen GE, Snow GL, Rodriguez L, Hopkins RO: Patients with respiratory failure increase ambulation after transfer to an intensive care unit where early activity is a priority. Crit Care Med Vol. 2008 36, No. 4: 1119-24

Dean E. Mobilizing patients in the ICU: Evidence and Principles of Practice. Acute Care Perspectives. Spring 2008, Vol 17, Number 1, 1-9. free text

Brown CJ, Redden DT, Flood KL, Allman RM. The underrecognized epidemic of low mobility during hospitalization of older adults. J Am Geriatr Soc. 2009 Sep;57(9):1660-5

Flanders SA, Harrington L, Fowler RJ. Falls and patient mobility in critical care: keeping patients and staff safe. AACN Adv Crit Care. 2009 Jul-Sep;20(3):267-76

Needham, DM, Truong AD, Fan E. Technology to enhance physical rehabilitation of critically ill patients. Crit Care Med 2009 Vol. 37, No. 10 (Suppl.) S436-441

Fan E, Zanni JM, Dennison CR, Lepre SJ, Needham DM. Critical illness neuromyopathy and muscle weakness in patients in the intensive care unit. AACN Adv Crit Care. 2009 Jul-Sep;20(3):243-53

Schweickert et al.: Early physical and occupational therapy in mechanically ventilated, critically ill patients: a randomised controlled trial. Lancet. 2009 May 30;373(9678):1874-82

Perme C, Chandrashekar R: Early mobility and walking program for patients in intensive care units: creating a standard of care. American Journal of Critical Care 2009 May;18(3):212-21. free full text

Needham DM, Korupolu R, Zanni JM, Pradhan P, Colantuoni E, Palmer JB, Brower RG, Fan E, (2010). Early Physical Medicine and Rehabilitation for Patients With Acute Respiratory Failure: A Quality Improvement Project. Arch Phys Med Rehabil Vol 91, 536-542

Needham DM, Korupulou R. Rehabilitation Quality Improvement in an Intensive Care Unit Setting: Implementation of a Quality Improvement Model. Top Stroke Rehabil 2010;17(4): 271–281

Korupolu R, Zanni JM, Fan E, Butler M, Needham DM. Early mobilisation of intensive care unit patient: the challenges of morbid obesity and multiorgan failure. BMJ Case Rep. 2010

Bourdin G Jack Barbier J, Burle J-F, Durante G, Passant, Vincent SB, Badet M, Bayle F, Richard JC and Claude Guerin C. The Feasibility of Early Physical Activity in Intensive Care Unit Patients: A Prospective Observational One-Center Study. Respir Care 2010;55(4):400– 407 free full text

Hinton MV. Establishing a Safe Patient Handling/Minimal Lift Program. Orthop Nurs. 2010 Sep-Oct;29(5):325-30

Zanni JM, Korupolu R, Fan E, et al. Rehabilitation therapy and outcomes in acute respiratory failure: An observational pilot project. J Crit Care 2010 Jun;25(2):254-62.

Pohlman MC, Schweickert WD, Pohlman AS, Nigos C, Pawlik AJ, Esbrook CL, Spears L, Miller M, Franczyk M, Deprizio D, Schmidt GA, Bowman A, Barr R, McCallister K, Hall JB, Kress JP. Feasibility of physical and occupational therapy beginning from initiation of mechanical ventilation. Crit Care Med. 2010 Nov;38(11):2089-94.

Arnold M, Radawiec S, Campo M, Wright LR. Changes in functional independence measure ratings associated with a safe patient handling and movement program. Rehabil Nurs. 2011 Jul-Aug;36(4):138-44. PubMed PMID: 21721394

Clini EM, Crisafulli E, Antoni FD, Beneventi C, Trianni L, Costi S, Fabbri LM, Nava S. Functional recovery following physical training in tracheotomized and chronically ventilated patients. Respir Care. 2011 Mar;56(3):306-13

Morris PE, Griffin L, Berry M, Thompson C, Hite RD, Winkelman C, Hopkins RO, Ross A, Dixon L, Leach S, Haponik E. Receiving early mobility during an intensive care unit admission is a predictor of improved outcomes in acute respiratory failure. Am J Med Sci. 2011 May;341(5):373-7.

Martin AD, Smith BK, Davenport PD, Harman E, Gonzalez-Rothi RJ, Baz M, Layon AJ, Banner MJ, Caruso LJ, Deoghare H, Huang TT, Gabrielli A. Inspiratory muscle strength training improves weaning outcome in failure to wean patients: a randomized trial. Critical Care 2011, 15:R84

Hodgin KE, Nordon-Craft A, MCFann KK, Mealer ML, Moss M. Physical therapy utilization in intensive care units: Results from a national survey. Critical Care Medicine 2009 Feb;37(2):561-6

Perme C, Lettvin C, Throckmorton TA, Mitchell K, Masud F. Early Mobility and Walking for Patients with Femoral Arterial Catheters in Intensive Care Unit: a Case Series. J. Acute Care Phys Ther; Spring 2011, Vol 2 , Number 1:30-34

Tzanis G, Vasileiadis I, Zervakis D, Karatzanos E, Dimopoulos S, Pitsolis T, Tripodaki E, Gerovasili V, Routsi C, Nanas S. Maximum inspiratory pressure, a surrogate parameter for the assessment of ICU-acquired weakness. BMC Anesthesiol. 2011 Jun 26;11:14.

Benington S, McWilliams D, Eddleston J, Atkinson D. Exercise testing in survivors of intensive care--is there a role for cardiopulmonary exercise testing? J Crit Care. 2012 Feb;27(1):89-94

Bierbrauer J, Koch S, Olbricht C, Hamati J, Lodka D, Schneider J, Luther-Schröder A, Kleber C, Faust K, Wiesener S, Spies CD, Spranger J, Spuler S, Fielitz J, Weber-Carstens S. Early type II fiber atrophy in intensive care unit patients with nonexcitable muscle membrane. Crit Care Med. 2012 Feb;40(2):647-50.

Leditschke IA, Green M, Irvine J, Bissett B, Mitchell IA. What are the Barriers to Mobilizing Intensive Care Patients? Cardiopulmonary Physical Therapy Journal 2012, 23 (1): 26-29.

Lowman JD, Kirk TK, Clark DE. Physical Therapy Management of a Patient on Portable Extracorporeal Membrane Oxygenation as a Bridge to Lung Transplation: A Case Report. Cardiopulmonary Physical Therapy Journal 2012, 23 (1): 30-35.

Winkelman C, Johnson KD, Hejal R, Gordon NH, Rowbottom J, Daly J, Peereboom K, Levine AD. Examining the positive effects of exercise in intubated adults in ICU: A prospective repeated measures clinical study. Intensive Crit Care Nurs. 2012 Mar 27

Kamdar BB, Needham DM, Collop NA. Sleep deprivation in critical illness: its role in physical and psychological recovery. J Intensive Care Med. 2012 Mar-Apr;27(2):97-111

Baldwin CE, Paratz JD, Bersten AD. Body composition analysis in critically ill survivors: a comparison of bioelectrical impedance spectroscopy devices. JPEN J Parenter Enteral Nutr. 2012 May;36(3):306-15

Balas MC, Rice M, Chaperon C, Smith H, Disbot M, Fuchs B. Management of delirium in critically ill older adults. Crit Care Nurse. 2012 Aug;32(4):15-26. PubMed PMID: 22855075

Ohtake PJ, Strasser DC, Needham DM. Rehabilitation for people with critical illness: taking the next steps. Phys Ther. 2012 Dec;92(12):1484-8

Campo M, Shiyko MP, Margulis H, Darragh AR. Effect of a safe patient handling program on rehabilitation outcomes. Arch Phys Med Rehabil. 2013 Jan;94(1):17-22

Rahimi RA, Skrzat J, Reddy DRS, Zanni JM, Fan E, Stephens RS, Needham DM.   Physical Rehabilitation of Intensive Care Patients Requiring Extracorporeal Membrane Oxygenation: A Small Case Series.  Physical Therapy 2013 Feb;93(2):248-55.2013 Feb;93(2):248-55

Kamdar BB, King LM, Collop NA, Sakamuri S, Colantuoni E, Neufeld KJ, Bienvenu OJ, Rowden AM, Touradji P, Brower RG, Needham DM.  The effect of a quality improvement intervention on perceived sleep quality and cognition in a medical ICU.  Critical Care Medicine 2013 Mar;41(3):800-9

Damluji A, Zanni JM, Mantheiy E, Colantuoni E, Kho ME, Needham DM. Safety and feasibility of femoral catheters during physical rehabilitation in the intensive care unit.J Crit Care. 2013 Aug;28(4):535.e9-15

Lord RK, Mayhew CR, Korupolu R, Mantheiy EC, Friedman MA, Palmer JB, Needham DM. ICU early physical rehabilitation programs: financial modeling of cost savings. Critical Care Medicine 2013 Mar;41(3):717-24.

Rahimi RA, Skrzat J, Reddy DRS, Zanni JM, Fan E, Stephens RS, Needham DM.   Physical Rehabilitation of Intensive Care Patients Requiring Extracorporeal Membrane Oxygenation: A Small Case Series.  Physical Therapy 2013; In press.

APTA. The Role of Physical Therapy in Safe Patient Handling. 2012; DOI: http://www.apta.org/uploadedFiles/APTAorg/About_Us/Policies/Practice/SafePatientHandling.pdf.

Titsworth WL, Hester J, Correia T, Reed R, Guin P, Archibald L, Layon AJ, Mocco J. The effect of increased mobility on morbidity in the neurointensive care unit. J Neurosurg. 2012 Jun;116(6):1379-88.

Hopkins RO, Miller RR 3rd, Rodriguez L, Spuhler V, Thomsen GE. Physical Therapy on the Wards After Early Physical Activity and Mobility in the Intensive Care Unit.Phys Ther. 2012; 92: 1518-1523.

Talley CL, Wonnacott RO, Schuette JK, Jamieson J, Heung M. Extending the benefits of early mobility to critically ill patients undergoing continuous renal replacement therapy: the Michigan experience. Crit Care Nurs Q. 2013 Jan-Mar;36(1):89-100

Dinglas, V. D., Colantuoni, E., Ciesla, N., Mendez-Tellez, P. A., Shanholtz, C., & Needham, D. M. (2013). Brief Report— Occupational therapy for patients with acute lung injury: Factors associated with time to first intervention in the intensive care unit.American Journal of Occupational Therapy, 67, 355–362.

Perme C, Nalty T, Winkelman C, Kenji Nawa R, Masud F. Safety and Efficacy of Mobility Interventions in Patients with Femoral Catheters in the ICU: A Prospective Observational Study. Cardiopulm Phys Ther J. 2013 Jun;24(2):12-7.

Choong K, Koo KK, Clark H, Chu R, Thabane L, Burns KE, Cook DJ, Herridge MS, Meade MO. Early Mobilization in Critically Ill Children: A Survey of Canadian Practice. Crit Care Med. 2013 Jul;41(7):1745-1753.

Engel HJ, Tatebe S, Alonzo PB, Mustille RL, Rivera MJ. Physical therapist-established intensive care unit early mobilization program: quality improvement project for critical care at the university of california san francisco medical center. Phys Ther. 2013 Jul;93(7):975-85.

Castro AA, Calil SR, Freitas SA, Oliveira AB, Porto EF. Chest physiotherapy effectiveness to reduce hospitalization and mechanical ventilation length of stay, pulmonary infection rate and mortality in ICU patients. Respir Med. 2013 Jan;107(1):68-74.

Davis J, Crawford K, Wierman H, Osgood W, Cavanaugh J, Smith KA, Mette S, Orff S. Mobilization of Ventilated Older Adults. J Geriatr Phys Ther. 2013 Mar 8.

Bloch SA, Lee JY, Wort SJ, Polkey MI, Kemp PR, Griffiths MJ. Sustained elevation of circulating growth and differentiation factor-15 and a dynamic imbalance in mediators of muscle homeostasis are associated with the development of acute muscle wasting following cardiac surgery. Crit Care Med. 2013 Apr;41(4):982-9

Sossdorf M, Otto GP, Menge K, Claus RA, Lösche W, Kabisch B, Kohl M, Smolenski UC, Schlattmann P, Reinhart K, Winning J. Potential effect of physiotherapeutic treatment on mortality rate in patients with severe sepsis and septic shock: A retrospective cohort analysis. J Crit Care. 2013 28(6):954-8.

Peiris CL, Shields N, Brusco NK, Watts JJ, Taylor NF.: Additional Saturday rehabilitation improves functional independence and quality of life and reduces length of stay: a randomized controlled trial. BMC Medicine 2013 11:198.

Parker AM, Lord RK, Needham DM. Increasing the dose of acute rehabilitation: is there a benefit? BMC Medicine 2013, 11:199

Balas MC, Burke WJ, Gannon D, Cohen MZ, Colbrun L, Bevil C, Franz D, Olsen KM, Ely WE: Implementing the Awakening and Breathing Coordination, Delirium Monitoring/Management, and Early Exercise/Mobility Bundle into Everyday Care: Opportunities, Challenges, and Lessons Learned for Implementing the ICU Pain, Agitation, and Delirium Guidelines. Critical Care Medicine 2013, 41 (9): S116-127.

Hanekom S, Louw QA, Coetzee AR. Implementation of a protocol facilitates evidence-based physiotherapy practice in intensive care units. Physiotherapy 99 (2013) 139–145.

Hill K, Diane M. Dennis DM, Patman SM. Relationships between mortality, morbidity, and physical function in adults who survived a period of prolonged mechanical ventilation. Journal of Critical Care (2013) 28, 427–432

Denehy L, Skinner EH, Edbrooke L, Haines K, Warrillow S, Hawthorne G, Gough K, Hoorn SV, Morris ME, Berney S. Exercise rehabilitation for patients with critical illness: a randomized controlled trial with 12 months of follow-up. Crit Care. 2013 Jul 24;17(4):R156.

Mendez-Tellez PA, Dinglas VD, Colantuoni E, Ciesla N, Sevransky JE, Shanholtz C, Pronovost PJ, Needham DM. Factors associated with timing of initiation of physical therapy in patients with acute lung injury. J Crit Care. 2013 Dec;28(6):980-4.

Brummel NE, Girard TD, Ely EW, Pandharipande PP, Morandi A, Hughes CG, Graves AJ, Shintani A, Murphy E, Work B, Pun BT, Boehm L, Gill TM, Dittus RS, Jackson JC. Feasibility and safety of early combined cognitive and physical therapy for critically ill medical and surgical patients: the Activity and Cognitive Therapy in ICU (ACT-ICU) trial. Intensive Care Med. 2013 Nov 21. [Epub ahead of print]

Hodgson C, Needham D, Haines K, Bailey M, Ward A, Harrold M, Young P, Zanni J, Buhr H, Higgins A, Presneill J, Berney S. Feasibility and inter-rater reliability of the ICU Mobility Scale. Heart Lung. 2014 Jan-Feb;43(1):19-24.

Balas MC, Vasilevskis EE, Olsen KM, Schmid KK, Shostrom V, Cohen MZ, Peitz G, Gannon DE, Sisson J, Sullivan J, Stothert JC, Lazure J, Nuss SL, Jawa RS, Freihaut F, Ely EW, Burke WJ. Effectiveness and safety of the awakening and breathing coordination, delirium monitoring/management, and early exercise/mobility bundle.Crit Care Med. 2014 May;42(5):1024-36.

Needham DM, Wozniak AW, Hough CL, Morris PE, Dinglas VD, Jackson JC, Mendez-Tellez PA, Shanholtz C, Ely EW, Colantuoni E, Hopkins RO, National Institutes of Health NHLBI ARDS Network. Risk factors for physical impairment after acute lung injury in a national, multicenter study. Am J Respir Crit Care Med. 2014 May 15;189(10):1214-24

Nawa RK, Lettvin C, Winkelman C, Evora PRB, Perme C. Initial inter-rater reliability for a novel measure of patient mobility in a Cardiovascular ICU. Journal of critical care 3 February 2014 (Article in Press DOI: 10.1016/j.jcrc.2014.01.019)

Sricharoenchai T, Parker AM, Zanni JM, Nelliot A, Dinglas VD, Needham DM. Safety of physical therapy interventions in critically ill patients: a single-center prospective evaluation of 1110 intensive care unit admissions. J Crit Care. 2014 Jun;29(3):395-400.

Abrams et al. (2014). Early mobilization of patients receiving extracorporeal membrane oxygenation: a retrospective cohort study Critical Care 18:R38.

Engel HJ, Needham DM, Morris PE, Gropper MA (2013). ICU Early Mobilization: From Recommendation to Implementation at Three Medical Centers. Crit Care Med 41:S69-S80

Hickmann CE, Roeseler J, Castanares-Zapatero D, Herrera EI, Mongodin A, Laterre PF. Energy expenditure in the critically ill performing early physical therapy. Intensive Care Med. 2014 Apr;40(4):548-55.

Haines KJ, Skinner EH, Berney S; Austin Health POST Study Investigators (2013). Association of postoperative pulmonary complications with delayed mobilisation following major abdominal surgery: an observational cohort study. Physiotherapy 99(2):119-25.

Nydahl P, Ruhl AP, Bartoszek G, Dubb R, Filipovic S, Flohr HJ, Kaltwasser A, Mende H, Rothaug O, Schuchhardt D, Schwabbauer N, Needham DM. Early mobilization of mechanically ventilated patients: a 1-day point-prevalence study in Germany. Crit Care Med. 2014 May;42(5):1178-86.

Berney SC, Harrold M, Webb SA, Seppelt I, Patman S, Thomas PJ, Denehy L. Intensive care unit mobility practices in Australia and New Zealand: a point prevalence study. Crit Care Resusc. 2013 Dec;15(4):260-5

Abrams D, Javidfar J, Farrand E, Mongero LB, Agerstrand CL, Ryan P, Zemmel D, Galuskin K, Morrone TM, Boerem P, Bacchetta M, Brodie D. Early mobilization of patients receiving extracorporeal membrane oxygenation: a retrospective cohort study. Crit Care. 2014 Feb 27;18(1):R38.

Hickmann CE, Roeseler J, Castanares-Zapatero D, Herrera EI, Mongodin A, Laterre PF. Energy expenditure in the critically ill performing early physical therapy. Intensive Care Med. 2014 Apr;40(4):548-55.

Girbes ARJ, Elbers PWG. Speech in an Orally Intubated Patient. N Engl J Med 2014; 370:1172-1173

Sprenkle, Kamille J.; Pechulis, Michael. Early Mobility of Patients Poststroke in the Neuroscience Intensive Care Unit. Journal of Acute Care Physical Therapy, 2013 4 (3): 101-109.

Nawa RK, Lettvin C, Winkelman C, Evora PR, Perme C. Initial interrater reliability for a novel measure of patient mobility in a cardiovascular intensive care unit. J Crit Care. 2014 Jun;29(3):475.e1-5.

Clemmer TP. Why the reluctance to meaningfully mobilize ventilated patients? "The answer my friend is blowin' in the wind". Crit Care Med. 2014 May;42(5):1308-9.

Doherty-King B, Bowers BJ. Attributing the responsibility for ambulating patients: a qualitative study. Int J Nurs Stud. 2013 Sep;50(9):1240-6.

Jackson JC, Santoro MJ, Ely TM, Boehm L, Kiehl AL, Anderson LS, Ely EW. Improving patient care through the prism of psychology: application of Maslow's hierarchy to sedation, delirium, and early mobility in the intensive care unit. J Crit Care. 2014 Jun;29(3):438-44.

Burry LD1, Williamson DR, Perreault MM, Rose L, Cook DJ, Ferguson ND, Lapinsky SC, Mehta S. Analgesic, sedative, antipsychotic, and neuromuscular blocker use in Canadian intensive care units: a prospective, multicentre, observational study. Can J Anaesth. 2014 Jul;61(7):619-30.

Greening NJ, Williams JE, Hussain SF, Harvey-Dunstan TC, Bankart MJ, Chaplin EJ, Vincent EE, Chimera R, Morgan MD, Singh SJ, Steiner MC. An early rehabilitation intervention to enhance recovery during hospital admission for an exacerbation of chronic respiratory disease: randomised controlled trial. BMJ. 2014 Jul 8;349:g4315.

Batterham AM, Bonner S, Wright J, Howell SJ, Hugill K, Danjoux G. Effect of supervised aerobic exercise rehabilitation on physical fitness and quality-of-life in survivors of critical illness: an exploratory minimized controlled trial (PIX study). Br J Anaesth. 2014 Jul;113(1):130-7.

Brownback CA, Fletcher P, Pierce LN, Klaus S. Early mobility activities during continuous renal replacement therapy. Am J Crit Care. 2014 Jul;23(4):348-51

Zebuhr C, Sinha A, Skillman H, Buckvold S. Active rehabilitation in a pediatric extracorporeal membrane oxygenation patient. PM R. 2014 May;6(5):456-60.

Hoyer EH, Brotman DJ, Chan K, Needham DM. Barriers to Early Mobility of Hospitalized General Medicine Patients: Survey Development and Results. Am J Phys Med Rehabil. 2014 Aug 15.

Wang YT, Haines TP, Ritchie P, Walker C, Ansell TA, Ryan DT, Lim PS, Vij S, Acs R, Fealy N, Skinner EH. Early mobilization on continuous renal replacement therapy is safe and may improve filter life. Crit Care. 2014 Jul 28;18(4):R161.

Rose L, Fowler RA, Fan E, Fraser I, Leasa D, Mawdsley C, Pedersen C, Rubenfeld G; the CANuVENT group. Prolonged mechanical ventilation in Canadian intensive care units: A national survey. J Crit Care. 2014 Jul 31. pii: S0883-9441(14)00312-8.

Rajesh Chawla, Sheila Nainan Myatra, Nagarajan Ramakrishnan, Subhash Todi, Sudha Kansal, and Sananta Kumar Dash Current practices of mobilization, analgesia, relaxants and sedation in Indian ICUs: A survey conducted by the Indian Society of Critical Care Medicine Indian J Crit Care Med. Sep 2014; 18(9): 575–584.

Pruijsten R, van Thiel R, Hool S, Saeijs M, Verbiest M, Reis Miranda D. Mobilization of patients on venovenous extracorporeal membrane oxygenation support using an ECMO helmet. Intensive Care Med. 2014 Oct;40(10):1595-7.

Patel BK, Pohlman AS, Hall JB, Kress JP. Impact of early mobilization on glycemic control and ICU-acquired weakness in critically ill patients who are mechanically ventilated. Chest. 2014 Sep;146(3):583-9.

Dinglas VD, Parker AM, Reddy DR, Colantuoni E, Zanni JM, Turnbull AE, Nelliot A, Ciesla N, Needham DM. A quality improvement project sustainably decreased time to onset of active physical therapy intervention in patients with acute lung injury. Ann Am Thorac Soc. 2014 Oct;11(8):1230-8.

Manzano F, Colmenero M, Pérez-Pérez AM, Roldán D, Jiménez-Quintana Mdel M, Mañas MR, Sánchez-Moya MA, Guerrero C, Moral-Marfil MA, Sánchez-Cantalejo E, Fernández-Mondéjar E. Comparison of two repositioning schedules for the prevention of pressure ulcers in patients on mechanical ventilation with alternating pressure air mattresses. Intensive Care Med. 2014 Nov;40(11):1679-87.

Jolley SE, Caldwell E, Hough CL. Factors associated with receipt of physical therapy consultation in patients requiring prolonged mechanical ventilation. Dimens Crit Care Nurs. 2014 May-Jun;33(3):160-7.

McWilliams D, Weblin J, Atkins G, Bion J, Williams J, Elliott C, Whitehouse T, Snelson C. Enhancing rehabilitation of mechanically ventilated patients in the intensive care unit: A quality improvement project. J Crit Care. 2014 Oct 2. pii: S0883-9441(14)00401-8.

Momosaki R, Yasunaga H, Matsui H, Horiguchi H, Fushimi K, Abo M. Effect of Early Rehabilitation by Physical Therapists on In-hospital Mortality after Aspiration Pneumonia in the Elderly. Arch Phys Med Rehabil. 2014 Oct 6.

Brusco NK, Watts JJ, Shields N, Taylor NF. Are weekend inpatient rehabilitation services value for money? An economic evaluation alongside a randomized controlled trial with a 30 day follow up. BMC Med. 2014 May 29;12:89

Roberts M, Johnson LA, Lalonde TL. Early mobility in the intensive care unit: Standard equipment vs a mobility platform. Am J Crit Care. 2014 Nov;23(6):451-7.

Sneyers B, Laterre PF, Perreault MM, Wouters D, Spinewine A. Current practices and barriers impairing physicians¿ and nurses¿ adherence to analgo-sedation recommendations in the intensive care unit - a national survey. Crit Care. 2014 Dec 5;18(6):655.

Brodsky MB, González-Fernández M, Mendez-Tellez PA, Shanholtz C, Palmer JB, Needham DM. Factors associated with swallowing assessment after oral endotracheal intubation and mechanical ventilation for acute lung injury. Ann Am Thorac Soc. 2014 Nov 11.

Klein K, Mulkey M, Bena JF, Albert NM. Clinical and Psychologic Effects of Early Mobilization in Patients Treated in a Neurologic ICU: A Comparative Study. Crit Care Med. 2014 Dec 16.

Hanekom S, Van Aswegen H, Plani N, Patman S. Developing minimum clinical standards for physiotherapy in South African intensive care units: the nominal group technique in action. J Eval Clin Pract. 2014 Sep 29. doi: 10.1111/jep.12257.

Barber EA, Everard T, Holland AE, Tipping C, Bradley SJ, Hodgson CL. Barriers and facilitators to early mobilisation in Intensive Care: A qualitative study. Aust Crit Care. 2014 Dec 19. pii: S1036-7314(14)00170-2.

Tillquist M, Kutsogiannis DJ, Wischmeyer PE, Kummerlen C, Leung R, Stollery D, Karvellas CJ, Preiser JC, Bird N, Kozar R, Heyland DK. Bedside ultrasound is a practical and reliable measurement tool for assessing quadriceps muscle layer thickness. JPEN J Parenter Enteral Nutr. 2014 Sep;38(7):886-90

Barber EA, Everard T, Holland AE, Tipping C, Bradley SJ, Hodgson CL. Barriers and facilitators to early mobilisation in Intensive Care: A qualitative study. Aust Crit Care. 2014 Dec 19.

Jolley SE, Dale CR, Hough CL. Hospital-Level Factors Associated with Report of Physical Activity in Patients on Mechanical Ventilation across Washington State. Ann Am Thorac Soc. 2015 Jan 7

Collings N, Cusack R. A repeated measures, randomised cross-over trial, comparing the acute exercise response between passive and active sitting in critically ill patients.BMC Anesthesiol. 2015 Jan 13;15(1):1.

Toccolini BF, Osaku EF, de Macedo Costa CR, Teixeira SN, Costa NL, Cândia MF, Leite MA, de Albuquerque CE, Jorge AC, Duarte PA. Passive orthostatism (tilt table) in critical patients: Clinicophysiologic evaluation. J Crit Care. 2015 Jan 6.

TEAM Study Investigators. Early mobilization and recovery in mechanically ventilated patients in the ICU: a bi-national, multi-centre, prospective cohort study. Crit Care. 2015 Feb 26;19(1):81.

Knott A, Stevenson M, Harlow SKM. Benchmarking rehabilitation practice in the intensive care unit Journal of the Intensive Care Society 2015

Sommers J, HH Engelbert RHH, Dettling-Ihnenfeldt D, Gosselink R, Spronk PE, Nollet F, van der Schaaf M. Physiotherapy in the intensive care unit: an evidence-based, expert driven, practical statement and rehabilitation recommendations. Clin Rehabil doi:10.1177/0269215514567156

Witcher R, Stoerger L, Dzierba AL, Silverstein A, Rosengart A, Brodie D, Berger K. Effect of early mobilization on sedation practices in the neurosciences intensive care unit: A preimplementation and postimplementation evaluation. J Crit Care. 2015 Apr;30(2):344-7.

Sottile PD, Nordon-Craft A, Malone D, Luby D, Schenkman M, Moss M. Physical Therapist Treatment of Patients in the Neurological Intensive Care Unit: Description of Practice. Phys Ther. 2015 Feb 5.

Campbell MR, Fisher J, Anderson L, Kreppel E. Implementation of early exercise and progressive mobility: steps to success. Crit Care Nurse. 2015 Feb;35(1):82-8.

Parry SM, Granger CL, Berney S, Jones J, Beach L, El-Ansary D, Koopman R, Denehy L. Assessment of impairment and activity limitations in the critically ill: a systematic review of measurement instruments and their clinimetric properties.Intensive Care Med. 2015 Feb 5

Parry SM, Berney S, Granger CL, Dunlop DL, Murphy L, El-Ansary D, Koopman R, Denehy L. A new two-tier strength assessment approach to the diagnosis of weakness in intensive care: an observational study. Crit Care. 2015 Dec;19(1):780.

Segers J, Hermans G, Charususin N, Fivez T, Vanhorebeek I, Van den Berghe G, Gosselink R. Assessment of quadriceps muscle mass with ultrasound in critically ill patients: intra- and inter-observer agreement and sensitivity. Intensive Care Med. 2015 Mar;41(3):562-3.

Cohen S, Nathan JA, Goldberg AL. Muscle wasting in disease: molecular mechanisms and promising therapies. Nat Rev Drug Discov. 2015 Jan;14(1):58-74.

Hill NE, Saeed S, Phadke R, Ellis MJ, Chambers D, Wilson DR, Castells J, Morel J, Freysennet DG, Brett SJ, Murphy KG, Singer M. Detailed characterization of a long-term rodent model of critical illness and recovery. Crit Care Med. 2015 Mar;43(3):e84-96

Files DC, Liu C, Pereyra A, Wang ZM, Aggarwal NR, D'Alessio FR, Garibaldi BT, Mock JR, Singer BD, Feng X, Yammani RR, Zhang T, Lee AL, Philpott S, Lussier S, Purcell L, Chou J, Seeds M, King LS, Morris PE, Delbono O. Therapeutic exercise attenuates neutrophilic lung injury and skeletal muscle wasting. Sci Transl Med. 2015 Mar 11;7(278):278ra32.

Scrivener K, Jones T, Schurr K, Graham PL, Dean CM. After-hours or weekend rehabilitation improves outcomes and increases physical activity but does not affect length of stay: a systematic review. J Physiother. 2015 Apr;61(2):61-7.

Berney SC, Rose JW, Bernhardt J, Denehy L. Prospective observation of physical activity in critically ill patients who were intubated for more than 48 hours. J Crit Care. 2015 Mar 13.

Cottereau G, Dres M, Avenel A, Fichet J, Jacobs FM, Prat D, Hamzaoui O, Richard C, Antonello M, Sztrymf B. Handgrip Strength Predicts Difficult Weaning But Not Extubation Failure in Mechanically Ventilated Subjects. Respir Care. 2015 Mar 10.

Waters A, Hill K, Jenkins S, Johnston C, Mackney J.Discordance Between Distance Ambulated as Part of Usual Care and Functional Exercise Capacity in Survivors of Critical Illness Upon Intensive Care Discharge: Observational Study. Phys Ther. 2015 Apr 2.

Kayambu G, Boots R, Paratz J. Early physical rehabilitation in intensive care patients with sepsis syndromes: a pilot randomised controlled trial. Intensive Care Med. 2015 May;41(5):865-74.

Felten-Barentsz KM, Haans AJ, Slutsky AS, Heunks LM, van der Hoeven JG. Feasibility and safety of hydrotherapy in critically ill ventilated patients. Am J Respir Crit Care Med. 2015 Feb 15;191(4):476-7.

Rand ML, Darbinian JA. Effect of an Evidence-Based Mobility Intervention on the Level of Function in Acute Intracerebral and Subarachnoid Hemorrhagic Stroke Patients on a Neurointensive Care Unit. Arch Phys Med Rehabil. 2015 Feb 18.

Lehr CJ, Zaas DW, Cheifetz IM, Turner DA. Ambulatory extracorporeal membrane oxygenation as a bridge to lung transplantation: walking while waiting. Chest. 2015 May 1;147(5):1213-8.

Arnold SM, Dinkins M, Mooney LH, Freeman WD, Rawal B, Heckman MG, Davis OA. Very early mobilization in stroke patients treated with intravenous recombinant tissue plasminogen activator. J Stroke Cerebrovasc Dis. 2015 Jun;24(6):1168-73.

Miller MA, Govindan S, Watson SR, Hyzy RC, Iwashyna TJ. ABCDE, but in That Order? A Cross-Sectional Survey of Michigan ICU Sedation, Delirium and Early Mobility Practices. Ann Am Thorac Soc. 2015 May 13.

Thomas K, Wright SE, Watson G, Baker C, Stafford V, Wade C, Chadwick TJ, Mansfield L, Wilkinson J, Shen J, Deverill M, Bonner S, Hugill K, Howard P, Henderson A, Roy A, Furneval J, Baudouin SV. Extra Physiotherapy in Critical Care (EPICC) Trial Protocol: a randomised controlled trial of intensive versus standard physical rehabilitation therapy in the critically ill. BMJ Open. 2015 May 25;5(5):e008035.

Jette DU, Stilphen M, Ranganathan VK, Passek S, Frost FS, Jette AM. Interrater Reliability of AM-PAC "6-Clicks" Basic Mobility and Daily Activity Short Forms. Phys Ther. 2015 May;95(5):758-66.

Eakin MN, Ugbah L, Arnautovic T, Parker AM, Needham DM. Implementing and sustaining an early rehabilitation program in a medical intensive care unit: A qualitative analysis. J Crit Care. 2015 Aug;30(4):698-704.

Pires-Neto RC, Lima NP, Cardim GM, Park M, Denehy L. Early mobilization practice in a single Brazilian intensive care unit. J Crit Care. 2015 May 19.

Poongkunran C, John SG, Kannan AS, Shetty S, Bime C, Parthasarathy S. A Meta-Analysis Of Sleep-Promoting Interventions During Critical Illness. Am J Med. 2015 Jun 10.

Skinner EH. Early physical rehabilitation may improve physical quality of life domains in patients admitted to ICU with sepsis syndromes. J Physiother. 2015 Jul;61(3):158.

Lima NP, Silva GM, Park M, Pires-Neto RC. Mobility therapy and central or peripheral catheter-related adverse events in an ICU in Brazil. J Bras Pneumol. 2015 May-Jun;41(3):225-30.

Elkins M, Dentice R. Inspiratory muscle training facilitates weaning from mechanical ventilation among patients in the intensive care unit: a systematic review. J Physiother. 2015 Jul;61(3):125-34.

Ko Y, Cho YH, Park YH, Lee H, Suh GY, Yang JH, Park CM, Jeon K, Chung CR. Feasibility and Safety of Early Physical Therapy and Active Mobilization for Patients on Extracorporeal Membrane Oxygenation. ASAIO J. 2015 Apr 23.

Malone D, Ridgeway K, Nordon-Craft A, Moss P, Schenkman M, Moss M. Physical Therapist Practice in the Intensive Care Unit: Results of a National Survey. Phys Ther. 2015 Jun 4.

Choong K, Al-Harbi S, Siu K, Wong K, Cheng J, Baird B, Pogorzelski D, Timmons B, Gorter JW, Thabane L, Khetani M; Canadian Critical Care Trials Group. Functional recovery following critical illness in children: the "wee-cover" pilot study. Pediatr Crit Care Med. 2015 May;16(4):310-8.

Owen HC, Vanhees I, Gunst J, Van Cromphaut S, Van den Berghe G. Critical illness-induced bone loss is related to deficient autophagy and histone hypomethylation.Intensive Care Med Exp. 2015 Dec;3(1):52.

Heyland DK, Stapleton RD, Mourtzakis M, Hough CL, Morris P, Deutz NE, Colantuoni E, Day A, Prado CM, Needham DM. Combining nutrition and exercise to optimize survival and recovery from critical illness: Conceptual and methodological issues. Clin Nutr. 2015 Jul 16.

Owen HC, Vanhees I, Gunst J, Van Cromphaut S, Van den Berghe G. Critical illness-induced bone loss is related to deficient autophagy and histone hypomethylation.Intensive Care Med Exp. 2015 Dec;3(1):52.

Kho ME, Martin RA, Toonstra AL, Zanni JM, Mantheiy EC, Nelliot A, Needham DM. Feasibility and safety of in-bed cycling for physical rehabilitation in the intensive care unit. J Crit Care. 2015 Jul 29.

Bain JC, Turner DA, Rehder KJ, Eisenstein EL, Davis RD, Cheifetz IM, Zaas DW. Economic Outcomes of Extracorporeal Membrane Oxygenation With and Without Ambulation as a Bridge to Lung Transplantation. Respir Care. 2015 Aug 11.

Reviews

Stiller K. Physiotherapy in intensive care: towards an evidence-based practice. Chest. 2000 Dec;118(6):1801-13.

Stiller K. Safety issues that should be considered when mobilizing critically ill patients.Crit Care Clin. 2007 Jan;23(1):35-53.

Choi J, Tasota FJ, Hoffman LA: Mobility interventions to improve outcomes in patients undergoing prolonged mechanical ventilation: a review of the literature. Biol Res Nurs. 2008 10(1):21-33. Review. free full text

Needham DM.: Mobilizing patients in the intensive care unit: improving neuromuscular weakness and physical function. JAMA. 2008 Oct 8;300(14):1685-90

Kress JP: Clinical trials of early mobilization of critically ill patients. Crit Care Med 2009; 37[Suppl.]:S442–S447

Chambers M, Moylan JS, Reid MB: Physical inactivity and muscle weakness in the critically ill. Crit Care Med 2009 Vol. 37, No. 10 (Suppl.): S337-S346

Brower RG: Consequences of bed rest. Crit Care Med 2009 Vol. 37, No. 10 (Suppl.): 422-428

Korupolu R, Gifford JM, Needham, DM. Early Mobilization of Critically Ill Patients: Reducing Neuromuscular Complications After Intensive Care. Contemporary Critical Care  2009, Vol 6 No 9: 1-10

Kho ME, Korupolu R, Needham DM. Early mobilization of critically ill patients: feasebility and benefits. ICU Mangemant 4 09/10: 31-33

Gosselink R, Clerckx B, Robbeets C, Vanhullebusch T, Vanpee G, J. Segers. Physiotherapy in the Intensive Care Unit. Neth J Crit Care 2011; 15(2):66-75

Adler J, Malone D. Early Mobilization in the Intensive Care Unit: A Systematic Review. Cardiopulmonary Physical Therapy Journal 2012, 23 (1): 5-13.

Berney S, Haines K, Denehy L. Physiotherapy in Critical Care in Australia. Cardiopulmonary Physical Therapy Journal 2012, 23 (1): 19-25.

Connolly B, Denehy L, Brett S, Elliott D, Hart N. Exercise rehabilitation following hospital discharge in survivors of critical illness: an integrative review. Crit Care. 2012 Jun 20;16(3):226.

Elliott D, Denehy L, Berney S, Alison JA. Assessing physical function and activity for survivors of a critical illness: a review of instruments. Aust Crit Care. 2011 Aug;24(3):155-66

Li Z, Peng X, Zhu B, Zhang Y, Xi X. Active Mobilization for Mechanically Ventilated Patients: A Systematic Review. Archives of physical medicine and rehabilitation. in press

Kayambu G, Boots R, Paratz J. Physical Therapy for the Critically Ill in the ICU: A Systematic Review and Meta-Analysis. Crit Care Med. 2013 Mar 29.

Batt J, dos Santos CC, Cameron JI, Herridge MS. Intensive care unit-acquired weakness: clinical phenotypes and molecular mechanisms. Am J Respir Crit Care Med. 2013 Feb 1;187(3):238-46

Stiller K. Physiotherapy in Intensive Care. An Updated Systematic Review. Chest. 2013 May 30. doi: 10.1378/chest.12-2930.

Engels PT, Beckett AN, Rubenfeld GD, Kreder H, Finkelstein JA, da Costa L, Papia G, Rizoli SB, Tien HC. Physical Rehabilitation of the Critically Ill Trauma Patient in the ICU. Crit Care Med. 2013 Jul;41(7):1790-1801.

Weaver SJ, Lubomksi LH, Wilson RF, Pfoh ER, Martinez KA, Dy SM. Promoting a culture of safety as a patient safety strategy: a systematic review. Ann Intern Med. 2013 Mar 5;158(5 Pt 2):369-74

Stiller K. Physiotherapy in intensive care: an updated systematic review. Chest. 2013 Sep;144(3):825-47.

Kayambu G, Boots R, Paratz J: Physical Therapy for the Critically Ill in the ICU: A Systematic Review and Meta-Analysis. Crit Care Med 2013, 41: 1543-54

Calvo-Ayala E, Khan BA, Farber MO, Ely EW, Boustani MA. Interventions to improve the physical function of ICU survivors: a systematic review. Chest. 2013 Nov 1;144(5):1469-80.

Mehlhorn J, Freytag A, Schmidt K, Brunkhorst FM, Graf J, Troitzsch U, Schlattmann P, Wensing M, Gensichen J. Rehabilitation interventions for postintensive care syndrome: a systematic review. Crit Care Med. 2014 May;42(5):1263-71.

Hakkennes S, Lindner C, Reid J. Implementing an inpatient rehabilitation Saturday service is associated with improved patient outcomes and facilitates patient flow across the health care continuum. Disabil Rehabil. 2014 Jul 23:1-7.

Harkin A. Muscling in on depression. N Engl J Med. 2014 Dec 11;371(24):2333-4.

Connolly B, MacBean V, Crowley C, Lunt A, Moxham J, Rafferty GF, Hart N. Ultrasound for the Assessment of Peripheral Skeletal Muscle Architecture in Critical Illness: A Systematic Review. Crit Care Med. 2014 Dec 31.

Verceles AC, Hager ER. Use of Accelerometry to Monitor Physical Activity in Critically Ill Subjects: A Systematic Review. Respir Care. 2015 Apr 7. pii: respcare.03677

Cameron S, Ball I, Cepinskas G, Choong K, Doherty TJ, Ellis CG, Martin CM, Mele TS, Sharpe M, Shoemaker JK, Fraser DD. Early mobilization in the critical care unit: A review of adult and pediatric literature. J Crit Care. 2015 Aug;30(4):664-672.

Connolly B, Salisbury L, O'Neill B, Geneen L, Douiri A, Grocott MP, Hart N, Walsh TS, Blackwood B; ERACIP Group. Exercise rehabilitation following intensive care unit discharge for recovery from critical illness. Cochrane Database Syst Rev. 2015 Jun 22;6:CD008632.

Blackwood B, Marshall J, Rose L. Progress on core outcome sets for critical care research. Curr Opin Crit Care. 2015 Aug 8.

Walsh CJ, Batt J, Herridge MS, Dos Santos CC. Muscle wasting and early mobilization in acute respiratory distress syndrome. Clin Chest Med. 2014 Dec;35(4):811-26.

Sosnowski K, Lin F, Mitchell ML, White H. Early rehabilitation in the intensive care unit: An integrative literature review. Aust Crit Care. 2015 Jul 1

Puthucheary ZA, Denehy L. Exercise Interventions in Critical Illness Survivors: Understanding Inclusion and Stratification Criteria. Am J Respir Crit Care Med. 2015 Jun 15;191(12):1464-7.

Liu Z, Tao X, Chen Y, Fan Z, Li Y. Bed rest versus early ambulation with standard anticoagulation in the management of deep vein thrombosis: a meta-analysis. PLoS One. 2015 Apr 10;10(4):e0121388.

Nyberg A, Saey D, Maltais F. Why and How Limb Muscle Mass and Function Should Be Measured in Patients with Chronic Obstructive Pulmonary Disease. Ann Am Thorac Soc. 2015 Sep;12(9):1269-77.

Jones CA, Roop SC, Pohar SL, Albrecht L, Scott SD. Translating knowledge in rehabilitation: systematic review. Phys Ther. 2015 Apr;95(4):663-77.

Guidelines, Protocols and Consensus Statements

Nici L, Donner C, Wouters E, Zuwallack R, Ambrosino N, Bourbeau J, Carone M, Celli B, Engelen M, Fahy B, Garvey C, Goldstein R, Gosselink R, Lareau S, MacIntyre N, Maltais F, Morgan M, O'Donnell D, Prefault C, Reardon J, Rochester C, Schols A, Singh S, Troosters T; ATS/ERS Pulmonary Rehabilitation Writing Committee. American Thoracic Society/European Respiratory Society statement on pulmonary rehabilitation. Am J Respir Crit Care Med. 2006

Gosselink R, Bott J, Johnson M et al.  Physiotherapy for adult patients with critical illness: Recommendations of the European Society of Intensive Care Medicine Task Force Physiotherapy for Critically Ill Patients.  Intensive Care Med 2008; 34:1188-1199

Gosselink R, Bott J, Johnson M, Dean E, Nava S, Norrenberg M, Schönhofer B, Stiller K, van de Leur H, Vincent JL. Physiotherapy for adult patients with critical illness: recommendations of the European Respiratory Society and European Society of Intensive Care Medicine Task Force on Physiotherapy for Critically Ill Patients.Intensive Care Med. 2008 Jul;34(7):1188-99.

National Institute for Health and Clinical Excellence (NICE):  Rehabilitation after critical illness. NICE Clinical Guideline No. 83, January 2009 http://www.nice.org.uk/CG83

Australian Guideline Physical Activity and Movement: A Guideline for Critically Ill Adults, Nov. 2014

Hodgson CL, Stiller K, Needham DM, Tipping CJ, Harrold M, Baldwin CE, Bradley S, Berney S, Caruana LR, Elliott D, Green M, Haines K, Higgins AM, Kaukonen KM, Leditschke I, Nickels MR, Paratz J, Patman S, Skinner EH, Young PJ, Zanni JM, Denehy L, Webb SA. Expert consensus and recommendations on safety criteria for active mobilization of mechanically ventilated critically ill adults. Crit Care. 2014 Dec 4;18(6):658

ICUAW - ICU acquired weakness

Research studies

Ferrando AA, Lane HW, Stuart CA, Davis-Street J, Wolfe RR. Prolonged bed rest decreases skeletal muscle and whole body protein synthesis. Am J Physiol. 1996 Apr;270(4 Pt 1):E627-33

Berek K, Margreiter J, Willeit J, Berek A, Schmutzhard E, Mutz NJ. Polyneuropathies in critically ill patients: a prospective evaluation. Intensive care medicine. 1996;22(9):849-55.

Hund E, Genzwurker H, Bohrer H, Jakob H, Thiele R, Hacke W. Predominant involvement of motor fibres in patients with critical illness polyneuropathy. British journal of anaesthesia. 1997;78(3):274-8.

Helliwell TR, Wilkinson A, Griffiths RD, McClelland P, Palmer TE, Bone JM. Muscle fibre atrophy in critically ill patients is associated with the loss of myosin filaments and the presence of lysosomal enzymes and ubiquitin. Neuropathology and applied neurobiology. 1998;24(6):507-17.

Zifko UA. Long-term outcome of critical illness polyneuropathy. Muscle Nerve Suppl. 2000;9:S49-52

Matsumoto N, Nakamura T, Yasui Y, Torii J. Analysis of muscle proteins in acute quadriplegic myopathy. Muscle & nerve. 2000;23(8):1270-6

de Letter MA, Schmitz PI, Visser LH, Verheul FA, Schellens RL, Op de Coul DA, van der Meché FG. Risk factors for the development of polyneuropathy and myopathy in critically ill patients. Crit Care Med. 2001 Dec;29(12):2281-6.

Sharma R, Anker SD. Cytokines, apoptosis and cachexia: the potential for TNF antagonism. Int J Cardiol. 2002 Sep;85(1):161-71.

De Jonghe B, Shanshar T, Lefaucheur JP et al.  Paresis acquired in the intensive care unit: A prospective multicenter study.  JAMA 2002; 288:2859-2867 free full text

Fredriksson K, Hammarqvist F, Strigard K, Hultenby K, Ljungqvist O, Wernerman J, et al. Derangements in mitochondrial metabolism in intercostal and leg muscle of critically ill patients with sepsis-induced multiple organ failure. American journal of physiology Endocrinology and metabolism. 2006;291(5):E1044-50.

Schweickert WD, Hall J. ICU-acquired weakness. Chest. 2007 May;131(5):1541-9

Winkelman C. Inactivity and inflammation in the critically ill patient. Crit Care Clin. 2007 Jan;23(1):21-34.

Hamburg NM, McMackin CJ, Huang AL, Shenouda SM, Widlansky ME, Schulz E, Gokce N, Ruderman NB, Keaney JF Jr, Vita JA. Physical inactivity rapidly induces insulin resistance and microvascular dysfunction in healthy volunteers. Arterioscler Thromb Vasc Biol. 2007 Dec;27(12):2650-6.

Hermans G, Wilmer A, Meersseman W, Milants I, Wouters PJ, Bobbaers H, Bruyninckx F, Van den Berghe G. Impact of intensive insulin therapy on neuromuscular complications and ventilator dependency in the medical intensive care unit. Am J Respir Crit Care Med. 2007 Mar 1;175(5):480-9.

Klaude M, Fredriksson K, Tjader I, Hammarqvist F, Ahlman B, Rooyackers O, et al. Proteasome proteolytic activity in skeletal muscle is increased in patients with sepsis. Clinical science. 2007;112(9):499-506.

Fink H, Helming M, Unterbuchner C, Lenz A, Neff F, Martyn JA, Blobner M. Systemic inflammatory response syndrome increases immobility-induced neuromuscular weakness. Crit Care Med. 2008 Mar;36(3):910-6.

Fredriksson K, Tjader I, Keller P, Petrovic N, Ahlman B, Scheele C, et al. Dysregulation of mitochondrial dynamics and the muscle transcriptome in ICU patients suffering from sepsis induced multiple organ failure. PloS one. 2008;3(11):e3686

Ahlbeck K, Fredriksson K, Rooyackers O, Maback G, Remahl S, Ansved T, et al. Signs of critical illness polyneuropathy and myopathy can be seen early in the ICU course. Acta anaesthesiologica Scandinavica. 2009;53(6):717-23.

Constantin D, McCullough J, Mahajan RP, Greenhaff PL. Novel events in the molecular regulation of muscle mass in critically ill patients. The Journal of physiology. 2011;589(Pt 15):3883-95.

Jespersen JG, Nedergaard A, Reitelseder S, Mikkelsen UR, Dideriksen KJ, Agergaard J, et al. Activated protein synthesis and suppressed protein breakdown signaling in skeletal muscle of critically ill patients. PloS one. 2011;6(3):e18090.

Bierbrauer J, Koch S, Olbricht C, Hamati J, Lodka D, Schneider J, Luther-Schröder A, Kleber C, Faust K, Wiesener S, Spies CD, Spranger J, Spuler S, Fielitz J, Weber-Carstens S. Early type II fiber atrophy in intensive care unit patients with nonexcitable muscle membrane. Crit Care Med. 2012 Feb;40(2):647-50.

Llano-Diez M, Renaud G, Andersson M, Marrero HG, Cacciani N, Engquist H, et al. Mechanisms underlying ICU muscle wasting and effects of passive mechanical loading. Critical care. 2012;16(5):R209.

Derde S, Hermans G, Derese I, Guiza F, Hedstrom Y, Wouters PJ, et al. Muscle atrophy and preferential loss of myosin in prolonged critically ill patients. Critical care medicine. 2012;40(1):79-89.

Klaude M, Mori M, Tjader I, Gustafsson T, Wernerman J, Rooyackers O. Protein metabolism and gene expression in skeletal muscle of critically ill patients with sepsis. Clinical science. 2012;122(3):133-42.

Renaud G, Llano-Diez M, Ravara B, Gorza L, Feng HZ, Jin JP, Cacciani N, Gustafson AM, Ochala J, Corpeno R, Li M, Hedström Y, Ford GC, Nair KS, Larsson L. Sparing of muscle mass and function by passive loading in an experimental intensive care unit model. J Physiol. 2013 Mar 1;591(Pt 5):1385-402.

Hermans G, Casaer MP, Clerckx B, Guiza F, Vanhullebusch T, Derde S, Meersseman P, Derese I, Mesotten D, Wouters PJ, Van Cromphaut S, Debaveye Y, Gosselink R, Gunst J, Wilmer A, Van den Berghe G, Vanhorebeek I. (2013). Effect of tolerating macronutrient deficit on the development of intensive-care unit acquired weakness: a subanalysis of the EPaNIC trial. The Lancet Respiratory Medicine 2013, 1(8): 621-629

Casaer MP, Langouche L, Coudyzer W, Vanbeckevoort D, De Dobbelaer B, Güiza FG, Wouters PJ, Mesotten D, Van den Berghe G. Impact of early parenteral nutrition on muscle and adipose tissue compartments during critical illness. Crit Care Med. 2013 Oct;41(10):2298-309.

Weber-Carstens S, Schneider J, Wollersheim T, Assmann A, Bierbrauer J, Marg A, Al Hasani H, Chadt A, Wenzel K, Koch S, Fielitz J, Kleber C, Faust K, Mai K, Spies CD, Luft FC, Boschmann M, Spranger J, Spuler S. Critical illness myopathy and GLUT4: significance of insulin and muscle contraction. Am J Respir Crit Care Med. 2013 Feb 15;187(4):387-96.

Puthucheary ZA, Rawal J, McPhail M, Connolly B, Ratnayake G, Chan P, Hopkinson NS, Phadke R, Dew T, Sidhu PS, Velloso C, Seymour J, Agley CC, Selby A, Limb M, Edwards LM, Smith K, Rowlerson A, Rennie MJ, Moxham J, Harridge SD, Hart N, Montgomery HE. Acute skeletal muscle wasting in critical illness. JAMA. 2013 Oct 16;310(15):1591-600.

Ackermann KA, Bostock H, Brander L, Schröder R, Djafarzadeh S, Tuchscherer D, Jakob SM, Takala J, Z'Graggen WJ. Early changes of muscle membrane properties in porcine faecal peritonitis. Crit Care. 2014 Aug 22;18(4):484.

Hooijman PE, Beishuizen A, de Waard MC, de Man FS, Vermeijden JW, Steenvoorde P, Bouwman RA, Lommen W, van Hees HW, Heunks LM, Dickhoff C, van der Peet DL, Girbes AR, Jasper JR, Malik FI, Stienen GJ, Hartemink KJ, Paul MA, Ottenheijm CA. Diaphragm fiber strength is reduced in critically ill patients and restored by a troponin activator. Am J Respir Crit Care Med. 2014 Apr 1;189(7):863-5

Herridge MS, Batt J, Santos CD. ICU-acquired weakness, morbidity, and death. Am J Respir Crit Care Med. 2014 Aug 15;190(4):360-2.

Wollersheim T, Woehlecke J, Krebs M, Hamati J, Lodka D, Luther-Schroeder A, Langhans C, Haas K, Radtke T, Kleber C, Spies C, Labeit S, Schuelke M, Spuler S, Spranger J, Weber-Carstens S, Fielitz J. Dynamics of myosin degradation in intensive care unit-acquired weakness during severe critical illness. Intensive Care Med. 2014 Apr;40(4):528-38.

Bloch SA, Lee JY, Syburra T, Rosendahl U, Griffiths MJ, Kemp PR, Polkey MI. Increased expression of GDF-15 may mediate ICU-acquired weakness by down-regulating muscle microRNAs. Thorax. 2015 Mar;70(3):219-28.

Fan E. Critical illness neuromyopathy and the role of physical therapy and rehabilitation in critically ill patients. Respir Care. 2012 Jun;57(6):933-44; discussion 944-6

Tillquist M, Kutsogiannis DJ, Wischmeyer PE, Kummerlen C, Leung R, Stollery D, Karvellas CJ, Preiser JC, Bird N, Kozar R, Heyland DK. Bedside ultrasound is a practical and reliable measurement tool for assessing quadriceps muscle layer thickness. JPEN J Parenter Enteral Nutr. 2014 Sep;38(7):886-90.

Connolly B, Thompson A, Douiri A, Moxham J, Hart N. Exercise-based rehabilitation after hospital discharge for survivors of critical illness with intensive care unit-acquired weakness: A pilot feasibility trial. J Crit Care. 2015 Jun;30(3):589-98.

Witteveen E, Hoogland IC, Wieske L, Weber NC, Verhamme C, Schultz MJ, van Schaik IN, Horn J. Assessment of ICU-acquired weakness in young and old mice: an E. coli septic peritonitis model. Muscle Nerve. 2015 May 26.

Wieske L, Dettling-Ihnenfeldt DS, Verhamme C, Nollet F, van Schaik IN, Schultz MJ, Horn J, van der Schaaf M. Impact of ICU-acquired weakness on post-ICU physical functioning: a follow-up study. Crit Care. 2015 Apr 27;19:196.

H Van Mechelen, G Hermans, F Bruyninckx, T Vanhullebusch, B Clerckx, P Meersseman, Y Debaveye, MP Casaer, A Wilmer, PJ Wouters, I Vanhorebeek, R Gosselink, G Van den Berghe Predictive value for weakness and 1-year mortality of screening electrophysiology tests in the ICU Crit Care. 2015; 19(Suppl 1): P474.

Reviews

Leijten FS, Harinck-de Weerd JE, Poortvliet DC, de Weerd AW. The role of polyneuropathy in motor convalescence after prolonged mechanical ventilation.JAMA. 1995 Oct 18;274(15):1221-5

Maramattom BV, Wijdicks EF. Acute neuromuscular weakness in the intensive care unit. Crit Care Med. 2006 Nov;34(11):2835-41

Hough CL, Needham DM. The role of future longitudinal studies in ICU survivors: understanding determinants and pathophysiology of weakness and neuromuscular dysfunction. Curr Opin Crit Care. 2007 Oct;13(5):489-96

Stevens RD, Dowdy DW, Michaels RK et al.  Neuromuscular dysfunction acquired in critical illness: a systematic review.  Intensive Care Med  2007; 33:1876-1891

Brower RG: Consequences of bed rest. Crit Care Med 2009 Vol. 37, No. 10 (Suppl.): 422-428.

Stevens RD, Marshall SA, Cornblath DR, Hoke A, Needham DM, de Jonghe B, Ali NA, Sharshar T. A framework for diagnosing and classifying intensive care unit-acquired weakness. Crit Care Med. 2009 Oct;37(10 Suppl):S299-308.

Lacomis D. Neuromuscular disorders in critically ill patients: review and update. J Clin Neuromuscul Dis. 2011 Jun;12(4):197-218.

Judemann K, Lunz D, Zausig YA, Graf BM, Zink W. [Intensive care unit-acquired weakness in the critically ill : critical illness polyneuropathy and critical illness myopathy]. Der Anaesthesist. 2011;60(10):887-901.

Bloch S, Polkey MI, Griffiths M, Kemp P. Molecular mechanisms of intensive care unit-acquired weakness. The European respiratory journal. 2012;39(4):1000-11.

Lee CM, Fan E. ICU-acquired weakness: what is preventing its rehabilitation in critically ill patients? BMC medicine. 2012;10:115.

Dos Santos CC, Batt J. ICU-acquired weakness: mechanisms of disability. Current opinion in critical care. 2012;18(5):509-17.

Batt J, dos Santos CC, Cameron JI, Herridge MS. Intensive care unit-acquired weakness: clinical phenotypes and molecular mechanisms. Am J Respir Crit Care Med. 2013 Feb 1;187(3):238-46.

Mohamed A, Ryan MM. Neuromuscular complications of intensive care. Handbook of clinical neurology. 2013;113:1481-3.

Koshy K, Zochodne DW. Neuromuscular complications of critical illness. Handbook of clinical neurology. 2013;115:759-80.

Lacomis D. Electrophysiology of neuromuscular disorders in critical illness. Muscle & nerve. 2013;47(3):452-63.

Kress JP, Hall JB. ICU-acquired weakness and recovery from critical illness. N Engl J Med. 2014 Apr 24;370(17):1626-35.

Argov Z, Latronico N. Neuromuscular complications in intensive care patients. Handbook of clinical neurology. 2014;121:1673-85.

Appleton RTD, Kinsella J, Quasim T. The incidence of intensive care unit-acquired weakness syndromes: A systematic review Journal of the Intensive Care Society 1751143714563016, first published on December 18, 2014 doi:10.1177/1751143714563016

Mehrholz J, Pohl M, Kugler J, Burridge J, Mückel S, Elsner B. Physical rehabilitation for critical illness myopathy and neuropathy. Cochrane Database Syst Rev. 2015 Mar 4;3:CD010942.

Hermans G, Van den Berghe G. Clinical review: intensive care unit acquired weakness. Crit Care. 2015 Aug 5;19:274.

Mehrholz J, Pohl M, Kugler J, Burridge J, Mückel S, Elsner B. Physical rehabilitation for critical illness myopathy and neuropathy. An abridged version of Cochrane Systematic Review. Eur J Phys Rehabil Med. 2015 Jul 9

Falvey JR, Mangione KK, Stevens-Lapsley JE. Rethinking Hospital-Associated Deconditioning: Proposed Paradigm Shift. Phys Ther. 2015 Sep;95(9):1307-15.

Guidelines

Fan E, Cheek F, Chlan L, Gosselink R, Hart N, Herridge MS, et al. An official American Thoracic Society Clinical Practice guideline: the diagnosis of intensive care unit-acquired weakness in adults. American journal of respiratory and critical care medicine. 2014;190(12):1437-46.

Neuromuscular electrical stimulation

Research studies

Bouletreau P, Patricot MC, Saudin F, Guiraud M, Mathian B. Effects of intermittent electrical stimulations on muscle catabolism in intensive care patients. JPEN J Parenter Enteral Nutr. 1987 Nov-Dec;11(6):552-5.

Zanotti E, Felicetti G, Maini M, Fracchia C. Peripheral muscle strength training in bed-bound patients with COPD receiving mechanical ventilation: effect of electrical stimulation. Chest. 2003 Jul;124(1):292-6. full free text

Gerovasili V, Stefanidis K, Vitzilaios K, Karatzanos E, Politis P, Koroneos A, Chatzimichail A, Routsi C, Roussos C, Nanas S. Electrical muscle stimulation preserves the muscle mass of critically ill patients: a randomized study. Crit Care. 2009;13(5):R161. Epub 2009 Oct 8. free full text

Gerovasili V, Tripodaki E, Karatzanos E, Pitsolis T, Markaki V, Zervakis D, Routsi C, Roussos C, Nanas S. Short-term systemic effect of electrical muscle stimulation in critically ill patients. Chest. 2009 Nov;136(5):1249-56. Epub 2009 Aug 26. free full text

Gruther W, Kainberger F, Fialka-Moser V, Paternostro-Sluga T, Quittan M, Spiss C, Crevenna R. Effects of neuromuscular electrical stimulation on muscle layer thickness of knee extensor muscles in intensive care unit patients: a pilot study. J Rehabil Med. 2010 Jun;42(6):593-7. free full text

Routsi C, Gerovasili V, Vasileiadis I, Karatzanos E, Pitsolis T, Tripodaki E, Markaki V, Zervakis D, Nanas S. Electrical muscle stimulation prevents critical illness polyneuromyopathy: a randomized parallel intervention trial. Crit Care. 2010;14(2):R74. Epub 2010 Apr 28. free full text

Poulsen JB, Møller K, Jensen CV, Weisdorf S, Kehlet H, Perner A. Effect of transcutaneous electrical muscle stimulation on muscle volume in patients with septic shock. Crit Care Med. 2011 Mar;39(3):456-61.

Fan E. Critical illness neuromyopathy and the role of physical therapy and rehabilitation in critically ill patients. Respir Care. 2012 Jun;57(6):933-44; discussion 944-6

Kho ME, Truong AD, Brower RG, Palmer JB, Fan E, Zanni JM, Ciesla ND, Feldman DR, Korupolu R, Needham DM. Neuromuscular electrical stimulation for ICU-acquired weakness: Protocol and methodological implications for a randomized, sham-controlled phase II trial. Physical Therapy Journal. 2012. In press (epublished)

Parry SM, Berney S, Koopman R, Bryant A, El-Ansary D, Puthucheary Z, Hart N, Warrillow S, Denehy L. Early rehabilitation in critical care (eRiCC): functional electrical stimulation with cycling protocol for a randomised controlled trial. BMJ Open. 2012;2(5)

J Segers, G Hermans, F Bruyninckx, G Meyfroidt, D Langer, and R Gosselink Feasibility of neuromuscular electrical stimulation in critically ill patients. Crit Care. 2013; 17(Suppl 2): P535.

Martin AD, Joseph AM, Beaver TM, Smith BK, Martin TD, Berg K, Hess PJ, Deoghare HV, Leeuwenburgh C. Effect of intermittent phrenic nerve stimulation during cardiothoracic surgery on mitochondrial respiration in the human diaphragm. Crit Care Med. 2014 Feb;42(2):e152-6.

Kho ME, Truong AD, Zanni JM, Ciesla ND, Brower RG, Palmer JB, Needham DM. Neuromuscular electrical stimulation in mechanically ventilated patients: A randomized, sham-controlled pilot trial with blinded outcome assessment. J Crit Care. 2014 Sep 22

Dirks ML, Hansen D, Van Assche A, Dendale P, Van Loon LJ. Neuromuscular electrical stimulation prevents muscle wasting in critically ill comatose patients. Clin Sci (Lond). 2015 Mar;128(6):357-65.

Iwatsu K, Yamada S, Iida Y, Sampei H, Kobayashi K, Kainuma M, Usui A. Feasibility of neuromuscular electrical stimulation immediately after cardiovascular surgery. Arch Phys Med Rehabil. 2015 Jan;96(1):63-8.

Parry SM, El-Ansary D, Cartwright MS, Sarwal A, Berney S, Koopman R, Annoni R, Puthucheary Z, Gordon IR, Morris PE, Denehy L. Ultrasonography in the intensive care setting can be used to detect changes in the quality and quantity of muscle and is related to muscle strength and function. J Crit Care. 2015 Jun 3.

Reviews

Maffiuletti NA, Roig M, Karatzanos E, Nanas S. Neuromuscular electrical stimulation for preventing skeletal-muscle weakness and wasting in critically ill patients: a systematic review. BMC Med. 2013 May 23;11:137

Parry SM, Berney S, Granger CL, Koopman R, El-Ansary D, Denehy L. Electrical muscle stimulation in the intensive care setting: a systematic review. Crit Care Med. 2013 Oct;41(10):2406-18.

Williams N, Flynn M. A review of the efficacy of neuromuscular electrical stimulation in critically ill patients. Physiother Theory Pract. 2014 Jan;30(1):6-11

Guidelines

Nici L, Donner C, Wouters E, Zuwallack R, Ambrosino N, Bourbeau J, Carone M, Celli B, Engelen M, Fahy B, Garvey C, Goldstein R, Gosselink R, Lareau S, MacIntyre N, Maltais F, Morgan M, O'Donnell D, Prefault C, Reardon J, Rochester C, Schols A, Singh S, Troosters T; ATS/ERS Pulmonary Rehabilitation Writing Committee. American Thoracic Society/European Respiratory Society statement on pulmonary rehabilitation. Am J Respir Crit Care Med. 2006

Gosselink R, Bott J, Johnson M et al.  Physiotherapy for adult patients with critical illness: Recommendations of the European Society of Intensive Care Medicine Task Force Physiotherapy for Critically Ill Patients.  Intensive Care Med 2008; 34:1188-1199

Dysphagia

Research studies

Neumeier AT, Moss M. We Need an Additional Seat at the Critical Care Multidisciplinary Team Table for our Speech-Language Pathologists. Ann Am Thorac Soc. 2014 Dec;11(10):1610-1.

Brodsky MB, González-Fernández M, Mendez-Tellez PA, Shanholtz C, Palmer JB, Needham DM. Factors associated with swallowing assessment after oral endotracheal intubation and mechanical ventilation for acute lung injury. Ann Am Thorac Soc. 2014 Dec;11(10):1545-52.

Suntrup S, Marian T, Schröder JB, Suttrup I, Muhle P, Oelenberg S, Hamacher C, Minnerup J, Warnecke T, Dziewas R. Electrical pharyngeal stimulation for dysphagia treatment in tracheotomized stroke patients: a randomized controlled trial. Intensive Care Med. 2015 Sep;41(9):1629-37.

Reviews

Guidelines

Team work

Research studies

Hopkins RO, Spuhler VJ, Thomsen GE: Transforming ICU culture to facilitate early mobility. Crit Care Clin. 2007 Jan;23 (1): 81-96

Thomsen GE, Snow GL, Rodriguez L, Hopkins RO: Patients with respiratory failure increase ambulation after transfer to an intensive care unit where early activity is a priority. Crit Care Med Vol. 2008 36, No. 4: 1119-24

Winkelman C, Peereboom K (2010): Staff-Perceived Barriers and Facilitators. Crit Care Nurse 30: 13-16

Bassett RD, Vollman KM, Brandwene L, Murray T. Integrating a multidisciplinary mobility programme into intensive care practice (IMMPTP): a multicentre collaborative. Intensive Crit Care Nurs. 2012 Apr;28(2):88-97

Karnatovskaia LV, Gajic O, Bienvenu OJ, Stevenson JE, Needham DM. A holistic approach to the critically ill and Maslow's hierarchy. J Crit Care. 2015 Feb;30(1):210-1.

Laerkner E, Egerod I, Hansen HP. Nurses' experiences of caring for critically ill, non-sedated, mechanically ventilated patients in the Intensive Care Unit: A qualitative study. Intensive Crit Care Nurs. 2015 Mar 2

Reviews

Rose L. Interprofessional collaboration in the ICU: how to define? Nursing in Criticial Care 2011, Vol 16 1: 5-10